Some common side effects may include:

1. Gastrointestinal issues: Nausea, vomiting, diarrhea, gas, bloating, or stomach pain are common gastrointestinal side effects. These issues often occur when starting metformin and may diminish as the body adjusts to the medication.
2. Loss of appetite: Metformin may cause a reduced appetite in some individuals, which can lead to weight loss.
3. Metallic taste: A metallic taste in the mouth is a possible side effect experienced by some people taking metformin.
4. Headache: Some users may experience headaches while taking metformin.
5. Weakness or fatigue: Metformin may cause feelings of weakness or fatigue in some individuals.
6. Vitamin B12 deficiency: Long-term use of metformin can be associated with reduced vitamin B12 absorption, potentially leading to a deficiency.

Remember that while these side effects are common, they may not affect everyone taking metformin.

Before using Tretinoin/Niacinamide Cream, keep in mind these essential safety tips:

1. Follow the prescription: Use the cream only as prescribed by your provider, adhering to the recommended dosage, frequency, and duration.
2. Avoid use during pregnancy and breastfeeding: Tretinoin is a retinoid and should not be used during pregnancy or breastfeeding due to the risk of potential harm to the developing baby.
3. Allergy information: Do not use the cream if you are allergic to any of its ingredients, including Tretinoin or Niacinamide. If you experience an allergic reaction, such as hives, swelling, or difficulty breathing, discontinue use and contact your healthcare provider immediately.
4. Sun protection: Tretinoin increases your skin’s sensitivity to sunlight, so it’s crucial to use a broad-spectrum sunscreen with at least SPF 30, wear protective clothing, and avoid prolonged sun exposure.
5. Avoid other skin irritants: While using Tretinoin/Niacinamide Cream, refrain from using other potentially irritating skincare products, such as abrasive cleansers, harsh exfoliants, or products containing alcohol.
6. Gradual introduction: If you experience skin irritation, consider using the cream every other day or even less frequently to allow your skin to adjust to the treatment. Consult your dermatologist for guidance on adjusting the application frequency.
7. Be patient: Skincare treatments, especially those targeting acne or signs of aging, may take weeks or months to show significant improvement. Be consistent with your application and follow your dermatologist’s recommendations.